Patients who use medicinal cannabis to treat migraines report an improvement in the migraine profile and the most common comorbidities. A reduction in prescription medications is also common, particularly opioids.6 Patients using medicinal cannabis for migraines also report a significant reduction in the number of migraines per month.< a href="#ref1">7 Medicinal cannabis appears to affect pain-sensitive processes in the brain and may interfere with the serotonergic and other signaling pathways involved in the development of migraines. 8 A study published in 2019 found that inhaled cannabis reduces the severity of headaches and migraines by about 50%.9 There is growing evidence for various therapeutic benefits of cannabis/cannabinoids, particularly in the treatment of pain, which could also apply to the treatment of migraines and headaches.10
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